Principal Investigators

Areas of Expertise

Full Core Members

Jeremy Chopek, Ph.D.

Assistant Professor, Physiology & Pathophysiology

Brainstem-spinal cord in-vitro electrophysiology, neuronal microcircuit formation, optogenetic and photomanipulation, transgenic mouse models, viral tracers, confocal micrscopy, chx10 brainstem neurons, spinal V3 interneurons, in-vivo electrophysiology, spinal cord injury and exercise, stretch reflexes, gene expression.

Kristine Cowley, Ph.D.

Assistant Professor, Physiology & Pathophysiology

In vitro electrophysiology and neuropharmacology, studies of spinal cord motor pattern generation and coordination, and adult rat spinal cord injury and motor training and recovery. Human neuromechanics, exercise physiology, and prevention and treatment of secondary complications of spinal cord injury.

Eftekhar Eftekharpour, Ph.D.

Assistant Professor, Physiology & Pathophysiology

Regeneration and Repair strategies for treatment of Spinal cord injury and Stroke. Pharmacological and Stem Cell Replacement Approaches to enhance neural cell protection, Manipulation of Redox Regulating systems in nervous system.

Brent Fedirchuk, Ph.D.

Associate Professor, Physiology & Pathophysiology

Electrical properties of motoneurons, modulation during locomotion, spinal motor circuitry.

Phillip F. Gardiner, Ph.D.

Professor, Physiology & Pathophysiology
Director, SCRC

Adaptations in spinal cord, neuromuscular junction and muscle to alterations in chronic activity levels; adaptability of biophysical, neurochemical and morphological properties of motoneurons.

Larry M. Jordan, Ph.D.

Professor, Physiology & Pathophysiology

Basic studies on brain and spinal cord systems controlling locomotion: genetic identification of core neuron groups, anatomical connectivity, relevant neurotransmitters and receptors, activity patterns of core neuron groups, and targeted deletion and activation. Restoration of locomotor function using spinal transplants of brainstem locomotor neurons.

Soheila Karimi, Ph.D.

Associate Professor, Physiology & Pathophysiology

Neural repair and regeneration in spinal cord injury and multiple sclerosis, regenerative medicine, neural stem cell biology and therapeutics, myelin biology and repair, preclinical modeling, CNS neuroinflammation and immune modulation, glial scar and matrix remodeling, pharmacological and bioengineered drug delivery systems for spinal cord regeneration, genetic models for studying neural differentiation and mechanisms, neural plasticity and neurological recovery in spinal cord injury and MS, cellular and molecular approaches in neuroscience, neuroanatomical and imaging techniques, primary in vitro models.

David A. McCrea, Ph.D.

Professor, Physiology & Pathophysiology

Spinal cord electrophysiology, spinal motor circuitry, pre- and postsynaptic control mechanisms.

James I. Nagy, Ph.D.

Professor, Physiology & Pathophysiology

Neurochemistry, neuroanatomy, biochemistry, cell biology, immunohistochemistry, models of spinal cord and brain injury, gap junction structure and function, CNS inflammatory mechanisms.

Brian J. Schmidt, M.D., FRCPC

M.D./Professor, Internal Medicine

In vitro electrophysiology and neuropharmacology, studies of spinal cord motor pattern generation.

Katinka Stecina, Ph.D.

Assistant Professor, Physiology & Pathophysiology

Electrophysiology, brain, spinal cord, function network analysis, interneurons, sensory-motor coordination, reflex, surface EMGs, nerve stimulation, transcranial magnetic stimulation.

Affiliate Members

Benedict C. Albensi, Ph.D.

Professor, Pharmacology & Therapeutics;
Manitoba Dementia Research Chair;
Everett Endowment Fund Chair

Role of NF-kB signaling in memory, and memory impairments from acute injury (TBI, stroke) and chronic disease (Alzheimer's, epilepsy), experiments at the molecular, cellular, tissue, and whole animal level using techniques such as Western blots, gel shift assays, in vitro electrophysiological recording (eg., LTP measurements), calcium analysis, in vivo MRI, and behavioral testing (Morris water maze).

Christopher M. Anderson, Ph.D.

Associate Professor, Pharmacology & Therapeutics
Director, Neuroscience Research Program
Manitoba Research Chair in Neurodegeneration
Kleysen Institute for Advanced Medicine (HSC & UM)

Neurovascular coupling, vascular dementia, two-photon imaging, astrocytes, brain ischemia, poly(ADP-ribose) polymerase, brain bioenergetics.

Marc Del Bigio, M.D., Ph.D., FRCPC

Professor, Department of Pathology (Neuropathology)
Professor, Department of Human Anatomy & Cell Science
Canada Research Chair in Developmental Neuropathology
Neuropathologist, Diagnostic Services Manitoba

Correlations human and animal neuropathology (developing to old age), histopathological assessment of brain, immunohistochemistry, electron microscopy, animal models of brain disease (stroke, trauma, hydrocephalus, toxin exposure)

Alan Casey, M.D.

M.D./Assistant Professor, Internal Medicine
Section of Physical Medicine and Rehabilitation
Spinal Cord Injury Inpatient Director, HSC

Physiatry, osteoporosis after spinal cord injury, spasticity.

Karen Ethans, M.D., FRCPC

M.D./Associate Professor, Internal Medicine
Section of Physical Medicine and Rehabilitation

Clinical specialist in medical rehabilitation, neuropharmacology, pain, spasticity, neurogenic bladder.

Paul Fernyhough, Ph.D.

Professor, Pharmacology & Therapeutics
Director, Division of Neurodegenerative Disorders

Diabetic and peripheral neuropathies, cell culture, confocal microscopy, fluorescence imaging, neuronal plasmid transfection, general biochemistry and pharmacology.

Gordon Glazner, Ph.D.

Associate Professor, Pharmacology & Therapeutics
Chief Scientific Officer - Contrimmune Biotechnology Inc.

Excitotoxicity, Alzheimer disease, stroke, aging, neuro-protection, signal transduction, gene expression, neurotrophic factors, apoptosis and necrosis.

Sari Hannila, Ph.D.

Associate Professor, Human Anatomy and Cell Science

Axonal regeneration, CNS myelin, MAG, SLPI, Smad2, TGF-beta signaling, reactive astrogliosis.

Jennifer Kornelsen, Ph.D.

Assistant Professor, Radiology

Spinal cord functional magnetic resonance imaging; human spinal cord neuroimaging; studies of sensory, motor, and affective processes in the spinal cord with spinal cord fMRI.

Dean J. Kriellaars, Ph.D.

Associate Professor, College of Rehabilitation Sciences

Human movement studies.

Benjamin Lindsey

Assistant Professor, Human Anatomy and Cell Science

Cellular imaging, fluorescence confocal, live in vivo imaging, correlative EM, tissue clearing, 3-D imaging, transgenics, immunohistochemistry, in situ hybridization, RNA-sequencing, neural stem cell behaviour.

Barbara L. Shay, Ph.D

Associate Professor and Department Head, Dept. of Physical Therapy, College of Rehabilitation Sciences

Neural control in movement, motion analysis, effects of descending neurotransmitters and modulation in the spinal cord.