Brent Fedirchuk, Ph.D.

Associate Professor, Physiology & Pathophysiology

University of Manitoba

Laboratory
410 BMSB
204-789-3274
Profile
Dr. Brent Fedirchuk obtained his Ph.D. from the University of Manitoba, in the Department of Physiology in 1994. He did postdoctoral work with Dr. Hans Hultborn in Copenhagen from 1993-1995, and with Dr. Michael O Donovan at the National Institutes of Health (U.S.A.) during 1995-1996. He returned to the University of Manitoba in 1996 as a Research Associate, and became an Assistant Professor in the Department of Physiology in July 2000.
Research
Dr. Fedirchuk’s research program is directed at how the electrical properties of spinal nerve cells are altered in preparation for a motor output. There is accumulating evidence, much of it from work done within our Spinal Cord Research Centre, that the properties of nerve cells innervating skeletal muscle (motoneurons) are altered during a behaviour like locomotion. Recently, it was found that the threshold properties of these neurons is altered; they become more excitable once locomotion has been initiated. Dr. Fedirchuk’s research program is aimed at determining the mechanism(s) underlying this modulation, and how the output of the spinal motor circuitry is affected. These mechanisms are likely used by the mammalian spinal cord to select appropriate portions of the motor circuitry for activation during a particular motor task. Knowledge of these cellular and pharmacological mechanisms could have important ramifications on treatment strategies designed to optimize motor function after spinal cord injury or degenerative disease.
Areas of Expertise
Electrical properties of motoneurons, modulation during locomotion, spinal motor circuitry.
Publications
Search PubMed for publications by Fedirchuk B
See Also
Dept. of Physiology & Pathophysiology profile for Dr. Fedirchuk
Division of Neurodegenerative Disorders

Education

  1. 1995-1996

    Postdoctoral Fellowship

    National Institutes of Health (U.S.A., Dr. Michael O'Donovan)
  2. 1993-1995

    Postdoctoral Fellowship

    Copenhagen University (Dr. Hans Hultborn)
  3. 1994

    Ph.D. in Physiology

    University of Manitoba

Academic Experience

  1. 2006-present
    Associate Professor
    University of Manitoba
  2. 2000-2006
    Assistant Professor
    University of Manitoba