Larry M. Jordan, Ph.D.
Professor, Physiology & Pathophysiology
University of Manitoba
- 425 BMSB
- Research in my laboratory is directed towards attaining an understanding of brain and spinal cord mechanisms for the initiation and control of locomotion. The overall goal of these studies is to develop strategies for the application of basic knowledge concerning the control of locomotion to the treatment of spinal cord disease and injury in humans. Ongoing projects include:
- An investigation of the pathways from the brain to the spinal cord which are essential for the initiation of locomotion, using metabolic mapping, anterograde and retrograde tracers, and electrophysiological and pharmacological characterization of descending locomotor command neurons.
- Studies of putative transmitter substances and other neuroactive substances as possible chemical mediators for the initiation of locomotion.
- An investigation of the spinal generator for locomotion by recording from identified neurons in the spinal cord during locomotor activity, determining their sites of termination, their actions on target cells, their pharmacological characteristics, and identifying markers.
- Mapping of locomotion-related spinal cord cells using activity-dependent immunohistochemical markers and electrophysiological methods, and evaluating their role in locomotion using pharmacological, genetic and optogenetic deletion or activation tools.
- Transplantation of identified locomotor command neurons into the spinal cord of animals with spinal cord injury to restore locomotor function, and providing novel methods to increase or decrease the activity of the transplanted cells.
- Dr. Brian Noga, Miami Project to Cure Paralysis, Miami, Florida
Dr. Keir Pearson, University of Alberta, Edmonton, Alberta
Dr. Serge Rossignol, University of Montreal, Montreal, Quebec, Canada
Dr. Urszula Slawinska, Nencki Institute of Experimental Biology, Warsaw, Poland
- Areas of Expertise
- Basic studies on brain and spinal cord systems controlling locomotion: genetic identification of core neuron groups, anatomical connectivity, relevant neurotransmitters and receptors, activity patterns of core neuron groups, and targeted deletion and activation. Restoration of locomotor function using spinal transplants of brainstem locomotor neurons.
- Search PubMed for publications by Jordan LM
- Erika Couto, Lab. Technician
- Katrina Armstrong, Ph.D. Student
- Mona Nazzal, Ph.D. Collaborative Studies Student (Univ. of Manitoba & Nencki Institute – Poland)